Longitudinal and cross-sectional study of retinal phenotypes and visual function in choroideremia carriers: a new grading system
We proposed a novel fundus grading system for choroideremia carriers and demonstrated its strong clinical utility and prognostic value. The granular type confers a favorable prognosis, whereas the other three types exhibit progressive deterioration. Baseline phenotypic grading is the best indicator of long-term outcomes, underscoring its value in clinical monitoring and therapeutic trial design.
Authors
- Zixi Sun (ORCID: https://orcid.org/0000-0002-8238-2115)
- Yaqing Yu (ORCID: https://orcid.org/0009-0005-6374-5645)
- X. Han
- Jiaqi Ding
- Ruifang Sui
- Xuan Zou
- Hui Li
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Medical Products Administration (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Eye and Vision
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1186/s40662-026-00476-2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences
- Peking Union Medical College Hospital