Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study
Higher birthweight within the normal range directly promotes healthy aging, mediated by multifaceted modifiable factors. Our findings advocate adopting a life-course approach to foster healthy aging, starting with optimal birthweight and extending to interventions that enhance socioeconomic status, promote healthy behaviors, strengthen physical functions, and prevent cardiometabolic diseases.
Authors
- Chaojie Ye (ORCID: https://orcid.org/0009-0009-7565-5048)
- Chun Dou (ORCID: https://orcid.org/0009-0005-9505-3707)
- Yuhong Chen (ORCID: https://orcid.org/0000-0002-4396-6353)
- Jieli Lu
- Yufang Bi
- Ruixin Liu
- Mingling Chen
- Min Xu
- Yu Li Xu
- Mian Li
- Weiqing Wang
- Jie Zheng
- Dong Liu
- Tiange Wang (ORCID: https://orcid.org/0000-0003-0723-489X)
- Zhiyun Zhao
- Guang Ning
- Lijie Kong
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1186/s12916-026-04737-8
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00