Brain Sphingolipid and Phospholipid Levels Are Altered in <scp>XK</scp> Disease
Our findings provide initial evidence of abnormal sphingolipid and phospholipid concentrations in the brains of XK patients and may provide insights into mechanisms of neurodegeneration in this disease. © 2026 International Parkinson and Movement Disorder Society.
Authors
- Renu Nandakumar
- Vasco A. Conceição (ORCID: https://orcid.org/0000-0003-2281-5748)
- Emma Thörn
- Klaudia Flóra Laborc
- Amie Hiller (ORCID: https://orcid.org/0000-0001-5912-6941)
- S Al-Sarraj
- SUSAN MORGELLO
- Ruth Walker
- Stephanie McQuillan
- Esther Sammler
- John Crary
- Claire Troakes
- Angelika Mühlebner
- Kurt Farrell
- Gabriel Miltenberger-Miltenyi
- Lily Yu-Chia Chiu
- Wim Van Hecke
- Henk-Jan Westeneng
- Randall Woltjer
- Zbigniew K Wszolek
- Claudia De Sanctis
Institutions
- Allen Institute for Brain Science (US)
- University of Lisbon (PT)
- Oregon Health & Science University (US)
- King's College London (GB)
- Utrecht University (NL)
- Columbia University Irving Medical Center (US)
- Jacksonville College (US)
- Ninewells Hospital (GB)
- University Medical Center Utrecht (NL)
- Hospital da Senhora da Oliveira Guimarães (PT)
- MRC Protein Phosphorylation and Ubiquitylation Unit (GB)
- James J. Peters VA Medical Center (US)
- National Institute on Aging (US)
- VA Portland Health Care System (US)
- Mayo Clinic in Florida (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1002/mds.70220
- Primary Topic
- Cellular transport and secretion
- Type
- article
- Field-Weighted Citation Impact
- 0.00