Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme (ISMNzyme)-modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidase-like, and glutathione peroxidase (GSH-Px)-like activities, alongside the controlled release of Fe<sup>2+</sup> and polysulfides. This dual mechanism induces ferroptosis-like bacterial death while concurrently promoting angiogenesis and osteogenesis. The platform represents a promising nanozyme-based strategy for the treatment of infected bone defects.

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Publication Details

Journal
ACS Nano
Published
2026-02-24
DOI
https://doi.org/10.1021/acsnano.5c20068
Primary Topic
Advanced Nanomaterials in Catalysis
Type
article
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article

Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

Yuanyu Hu, Lizeng Gao, Shilong Su, Zhongyu Wang et al.
ACS Nano
Advanced Nanomaterials in Catalysis
article

Multi-Activity Nanozyme-Integrated Scaffolds: Harnessing Synergistic Enzyme-like Effects for Complete Treatment of Infected Bone Defects

Yuanyu Hu, Lizeng Gao, Shilong Su, Zhongyu Wang, Zeqi Ren, J F Ye, Han Shuai, Peng Wen, Xiaolin Ma, Yubao Lu, Caimei Wang, Chaoxin Wang, Shengxin Zeng, Jiedong Wang, Yun Tian, Kaixi Liu, Kangchun Wang, Xing Peng, Qian Wang, Jiajia Zheng, Yufeng Zheng
article en

Abstract

Infected bone defects pose a major clinical challenge because they typically involve severe infection, poor vascularization, and bone loss. Existing implant materials lack integrated functionality for long-term infection control and tissue regeneration. Here, a multifunctional nanozyme platform consisting of a 3D-printed titanium scaffold functionalized with an iron sulfide multiactivity nanozyme (ISMNzyme)-modified hydrogel is introduced. The platform leverages synergistic peroxidase-like, myeloperoxidase-like, and glutathione peroxidase (GSH-Px)-like activities, alongside the controlled release of Fe<sup>2+</sup> and polysulfides. This dual mechanism induces ferroptosis-like bacterial death while concurrently promoting angiogenesis and osteogenesis. The platform represents a promising nanozyme-based strategy for the treatment of infected bone defects.

ACS NanoVol. 20(9)
Fujian Medical University (CN), Tribhuvan University (NP), Sun Yat-sen University (CN), Shenzhen University (CN), Capital Medical University (CN), Chinese Academy of Sciences (CN), Peking University (CN), Institute of Biophysics (CN), Shandong Provincial Hospital (CN), First Affiliated Hospital of Chinese PLA General Hospital (CN), Peking University Third Hospital (CN), Third Affiliated Hospital of Sun Yat-sen University (CN), Shandong First Medical University (CN), University of Chinese Academy of Sciences (CN), Indiana University School of Medicine, Southwest Jiaotong University (CN), Tsinghua University (CN)
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