Peripheral Metabolic–Redox Signaling as a Core Mechanism of Major Depressive Disorder: Evidence from Deep Metabolomic Phenotyping
The MDD metabotype represents a cohesive metabolic network that is associated with the NIMETOX pathogenesis of MDD. Metabolomics provides a comprehensive foundation for subtyping and precision psychiatry. Lipoxygenase-15, lipotoxicity, phospholipase A<sub>2</sub>, and lipid-redox intersections might be important drug targets to treat MDD.
Authors
- Annabel Maes
- Jin Li (ORCID: https://orcid.org/0000-0002-6131-456X)
- Chenkai Yangyang
- Michael Maes
- Mengqi Niu
- Yiping Luo
- Abbas F. Almulla
- Yingqian Zhang
Institutions
- University of Electronic Science and Technology of China (CN)
- Chulalongkorn University (TH)
- Medical University Plovdiv (BG)
- Kyung Hee University (KR)
Publication Details
- Journal
- Acta Neuropsychiatrica
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1017/neu.2026.10065
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cambridge
- Chengdu Science and Technology Program