Systolic Blood Pressure Targets in Patients With Hypertension With and Without Cardiovascular Disease: A Pooled Analysis of 4 Randomized Clinical Trials
Restricted cubic spline analyses demonstrated a J-shaped association between achieved SBP and major adverse cardiovascular event irrespective of CVD history. Maintaining SBP within 110 to 140 mm Hg was similarly associated with lower cardiovascular risk in patients with and without CVD. Risk appeared lowest when SBP was between 120 and 130 mm Hg, while an SBP target <110 mm Hg may offer additional benefit among patients without CVD.
Authors
- Zhixin Jiang (ORCID: https://orcid.org/0000-0003-0139-2352)
- Yizhen Lyu (ORCID: https://orcid.org/0000-0002-8376-0747)
- Juhua Zhang (ORCID: https://orcid.org/0000-0002-4231-8223)
- Wenming Bian
- Yezhou Liu
- Kangyu Chen
- Chao Li
- Yamei Liu
- Tao Chen
Institutions
- University of Science and Technology of China (CN)
- Liverpool School of Tropical Medicine (GB)
- Nanjing Medical University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Circulation Population Health and Outcomes
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1161/circoutcomes.125.012643
- Citations
- 1
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 30.07