A new hydroxybutanamide derivative from <i>Saussurea involucrata</i> with anti-PD activity on H <sub>2</sub> O <sub>2</sub> insult sH-SY5Y cells
A new hydroxybutanamide derivative, involucramide (<b>1</b>), was obtained from the traditional Chinese medicinal herb <i>Saussurea involucrata.</i> Five other isolates were characterised as betulinic acid (<b>2</b>), costunolide (<b>3</b>), dihydrocostunolide (<b>4</b>), isodihydrocostunolide (<b>5</b>), and dehydrocostus lactone (<b>6</b>). The structure of <b>1</b> was established through extensive data analyses encompassing its NMR, IR, UV, and HRESIMS data. All isolates were evaluated for the anti-PD activity on H<sub>2</sub>O<sub>2</sub>-insulted SH-SY5Y cells. Amongst them, compound <b>1</b> exhibited the potential activity with the EC<sub>50</sub> value of 6.84 <i>µ</i>M. Furthermore, at the concentration of 20 <i>µ</i>M, <b>1</b> attenuated the intracellular ROS accumulation, elevated the glutathione (GSH) levels, and reversed the downregulated mRNA expression of HO-1 and NQO1 in H<sub>2</sub>O<sub>2</sub>-injured SH-SY5Y cells.
Authors
- Chenlu Lv
- Yantao Shi
- Abdulla Yusuf (ORCID: https://orcid.org/0000-0002-0685-2381)
- Linzhen Hu
- Rongrong Dai
- Yuben Qiao
- Qi Huang
- Jie Shi
Institutions
- Chinese Academy of Sciences (CN)
- Tianjin Economic-Technological Development Area (CN)
- Tianjin Institute of Industrial Biotechnology (CN)
- Kashi University (CN)
- Huazhong University of Science and Technology (CN)
- Southern Medical University (CN)
- Hubei University (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1080/14786419.2026.2636164
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00