Prenatal exposure to metal mixtures and the risk of overweight and obesity in school-aged children: insights from metabolomic profiling

Prenatal Cu and V exposure may have an adverse effect on school-aged childhood's OWO risk, and metabolites may play an important intermediate role. By further examining metabolite profiles, our findings offer insight into potential metabolic pathways through which prenatal metal exposure may influence childhood obesity risk, thereby extending existing epidemiological evidence with a mechanistic perspective. Multi-center population studies and <i>in vivo</i> studies in future are needed to validate the results.