Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants

NSAA-engineered peptidomimetics act as pan-variant RBD inhibitors, resisting antigenic drift while preserving host-binding specificity. This computational-quantum hybrid strategy offers a blueprint for resilient antiviral therapeutics against evolving pathogens.

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Publication Details

Journal
Expert Opinion on Drug Discovery
Published
2026-02-23
DOI
https://doi.org/10.1080/17460441.2026.2625825
Primary Topic
vaccines and immunoinformatics approaches
Type
article
Field-Weighted Citation Impact
0.00
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article

Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants

Kapil Laddha, Tamás A. Martinek, M Elizabeth Sobhia, Stanly Paul Matam Losery
Expert Opinion on Drug Discovery
vaccines and immunoinformatics approaches
article

Computational insights and impact of combinatorial peptidomimetics on immune escape SARS-CoV-2 variants

Kapil Laddha, Tamás A. Martinek, M Elizabeth Sobhia, Stanly Paul Matam Losery
article en

Abstract

NSAA-engineered peptidomimetics act as pan-variant RBD inhibitors, resisting antigenic drift while preserving host-binding specificity. This computational-quantum hybrid strategy offers a blueprint for resilient antiviral therapeutics against evolving pathogens.

Expert Opinion on Drug DiscoveryVol. 21(3)
University of Szeged (HU)
Openalex Percentile: Top 44%
vaccines and immunoinformatics approaches
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