Enhancing colorectal cancer diagnosis with the ferroptosis marker GPX4 and serum biomarkers: A retrospective analysis and machine learning approach

Ferroptosis plays a critical role in CRC pathogenesis and progression. GPX4 was identified as a robust biomarker for early diagnosis. The integrated machine learning model, incorporating GPX4, CEA, CA19-9, and serum iron, demonstrated superior diagnostic performance compared to conventional markers, offering a promising strategy for the early detection of CRC.