Macrophages From Latently Infected Mice Have Trained Immunity to HSV-1
Collectively, our findings indicate that macrophages develop a durable trained immunity to HSV-1 infection, with IRGM1 emerging as a key component in the long-term maintenance of macrophage immunological memory.
Authors
- Ujjaldeep Jaggi (ORCID: https://orcid.org/0000-0002-6844-659X)
- Satoshi Hirose (ORCID: https://orcid.org/0000-0001-7825-501X)
- Homayon Ghiasi (ORCID: https://orcid.org/0000-0003-3291-1995)
- Shaohui Wang (ORCID: https://orcid.org/0000-0001-7764-0581)
- Deepak Arya (ORCID: https://orcid.org/0009-0007-2780-2029)
Institutions
- Cedars-Sinai Medical Center (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1167/iovs.67.2.49
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health