Real-world effectiveness and safety of Sacituzumab Govitecan in metastatic triple-negative breast cancer: results from the multicenter retrospective observational SACISUR cohort in Southern Spain

SG demonstrated effectiveness and tolerability in mTNBC patients treated in routine practice, including those with CNS metastases, consistent with ASCENT trial results. These findings support the use of SG in clinical practice for mTNBC patients and suggest clinically meaningful activity and a manageable safety profile in patients with CNS involvement, despite the clinical challenges presented by this subgroup.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-24
DOI
https://doi.org/10.3389/fonc.2026.1717135
Primary Topic
Advanced Breast Cancer Therapies
Type
article
Field-Weighted Citation Impact
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article

Real-world effectiveness and safety of Sacituzumab Govitecan in metastatic triple-negative breast cancer: results from the multicenter retrospective observational SACISUR cohort in Southern Spain

S. Estalella-Mendoza, Cristina Morales-Estévez, Rubén de Toro-Salas, Elena Vicente-Rubio et al.
Frontiers in Oncology
Advanced Breast Cancer Therapies
article

Real-world effectiveness and safety of Sacituzumab Govitecan in metastatic triple-negative breast cancer: results from the multicenter retrospective observational SACISUR cohort in Southern Spain

S. Estalella-Mendoza, Cristina Morales-Estévez, Rubén de Toro-Salas, Elena Vicente-Rubio, María Valero-Arbizu, Alba González-Haba, Ana Gil-Torralvo, Tamara Díaz-Redondo, Alberto Torres-Zurita, Elisenda Llabres-Valentí, Rocio Urbano-Cubero, Alicia Cano-Jimenez, Alejandro Falcón-González, Encarna González-Flores, Javier Pascual, Ana Godoy-Ortiz, Natalia Chavarría-Piudo, Estefanía Casaut-Lora, Julio César Nieto-Ramírez, Manuel Ruiz-Borrego, Irene Zarcos-Pedrinaci, David Morales-Pancorbo, Javier Salvador-Bofill, Jose Andrés Rodríguez-García, Icíar De la Fuente-Domínguez, Mónica Cejuela-Solís, Fernando Henao-Carrasco, Antonia Sánchez-Guisado, Braulio Martín-Calero, Josefina Cruz-Jurado, Ana Milena Vargas-Prado, Ariadna Acosta-Sánchez
article en

Abstract

SG demonstrated effectiveness and tolerability in mTNBC patients treated in routine practice, including those with CNS metastases, consistent with ASCENT trial results. These findings support the use of SG in clinical practice for mTNBC patients and suggest clinically meaningful activity and a manageable safety profile in patients with CNS involvement, despite the clinical challenges presented by this subgroup.

Frontiers in OncologyVol. 16
Hospital Universitario Insular de Gran Canaria (ES), Hospital Costa del Sol (ES), Hospital Universitario Virgen Macarena (ES), Instituto Maimónides de Investigación Biomédica de Córdoba (ES), Hospital Universitario de Gran Canaria Doctor Negrín (ES), Gobierno de Canarias (ES), Hospital Regional Universitario de Málaga (ES), Hospital Quirónsalud Barcelona (ES), Hospital Universitario Virgen de las Nieves (ES), Complejo Hospitalario de Jaén (ES), Institut thématique Génétique, génomique et bioinformatique (FR), Biomedical Research and Innovation Institute of Cadiz (ES), Hospital Juan Ramón Jiménez (ES), Hospital Materno-Infantil (ES), Centro de Implantología Cirugía Oral y Maxilofacial (ES), Hospital Universitario Puerto Real (ES), Hospital Universitario Puerta del Mar (ES), Complejo Hospitalario Torrecárdenas (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Clínico Universitario Virgen de la Victoria (ES), Medical Research Network (US), Instituto de Investigación Biomédica de Málaga (ES)
Good health and well-being
Openalex Percentile: Top 45%
Advanced Breast Cancer Therapies
DOIOpen Access PDFOpenAlex
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