Development and clinical application of biological dosimetry technology: insights from the HICARE/IAEA 2025 international training course

The HICARE/IAEA 2025 International Training Course on Biological and Internal Dosimetry, held at Hiroshima University from 10 to 14 February 2025, convened 20 participants from nine countries- Brazil, Indonesia, Japan, Korea, the Philippines, Singapore, Thailand, the United States, and Vietnam-and was jointly organized by the Hiroshima International Council for Health Care of the Radiation-Exposed (HICARE) and the International Atomic Energy Agency (IAEA). With guidance from 13 expert lecturers, the course aimed to enhance global capacity in radiation dose assessment and clinical application of biodosimetry. The program, led by Prof. Satoshi Tashiro (HICARE) and Dr. Oleg Belyakov (IAEA), included lectures on cytogenetic assays, molecular biomarkers, and internal dosimetry using biokinetic modeling and bioassay data. Key themes emphasized the integration of biodosimetry into clinical decision-making, emergency preparedness, and occupational health monitoring. Discussions highlighted the expanding role of biodosimetry in complementing internal dose assessments for patients undergoing diagnostic imaging procedures-such as CT scans and nuclear medicine-as well as for individuals affected by radiological accidents. These sessions underscored the need for harmonized protocols, reliable dose reconstruction methods, and cross-institutional networks to support accurate and timely biodosimetric evaluations in both clinical and emergency settings. The workshop not only had advanced technical competencies but also positioned biodosimetry as a critical tool in global radiological protection strategies. Strong participant engagement and interest in future events reflected the course's impact on strengthening international cooperation and translating research into practice.