Fiber intake associates with increased treatment response in multiple myeloma patients along changes in gut microbiome
Key Points High dietary fiber intake increases gut microbiome diversity and specific fibers link to MRD negativity in NDMM patients. Microbial signatures and butyrate-producing taxa segregate auto-HCT response and may link fiber intake to immune-modulating effects.
Authors
- Lukas John (ORCID: https://orcid.org/0000-0001-8178-6890)
- Philipp Reichert
- Lilli Sophie Sester
- Stefanie Huhn (ORCID: https://orcid.org/0000-0003-1700-2371)
- Jan Hendrik Frenking
- Simon Steiger (ORCID: https://orcid.org/0000-0002-4845-5042)
- Anna Chechenina
- David Vonhören
- Gernot Poschet (ORCID: https://orcid.org/0000-0002-5344-0865)
- E K
- Konstanze Lettau (ORCID: https://orcid.org/0009-0007-0522-5224)
- Nina Prokoph (ORCID: https://orcid.org/0000-0002-6429-9895)
- Mirco Friedrich (ORCID: https://orcid.org/0000-0002-6401-3623)
- Michael Kilian (ORCID: https://orcid.org/0000-0002-1946-3174)
- Anna Katharina Gambihler
- Carsten Müller-Tidow
- Sandra Sauer
- Karsten Rippe
- M. Platten
- Niels Weinhold
- Hartmut Goldschmidt
- Vadim Borisov
- Marc S. Raab
- Juliana de Castilhos
- Iuliia Galeeva
- Chris Philipp Kohlberger
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Heilbronn University (DE)
- DKFZ-ZMBH Alliance (DE)
- University of Tübingen (DE)
Publication Details
- Journal
- Blood Advances
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1182/bloodadvances.2025018598
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Bristol-Myers Squibb
- Pfizer
- GlaxoSmithKline
- Sanofi
- Celgene
- European Commission
- Deutsche Forschungsgemeinschaft
- Universitätsmedizin Mannheim
- HORIZON EUROPE Framework Programme
- Cilag