Cortex-Restricted Deletion of <i>Foxp1</i> Impairs Visual Responses by Disrupting Geniculocortical Connections in a Mouse Model of Autism
Foxp1-cKO mice have deficits in visual signal transmission and depth perception, indicating binocular vision abnormalities. This study highlights the importance of geniculocortical connectivity for binocular vision and offers new insights into the mechanisms underlying ASD-related visual impairments, suggesting future studies to explore therapies aimed at restoring mitochondrial function.
Authors
- Jieni Wang
- Chunpu Qu
- Xiaomeng Tu
- Qi Tang (ORCID: https://orcid.org/0000-0003-2385-4263)
- Xingyu Zhu (ORCID: https://orcid.org/0000-0002-5349-8071)
- Jialu Wu
- C. Wang
- Jie-Guang Chen
- Xue Li
Institutions
- Wenzhou Medical University (CN)
- Affiliated Eye Hospital of Wenzhou Medical College (CN)
- Lishui Central Hospital (CN)
- Lishui City People's Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1167/iovs.67.2.50
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00