Alterations to the bronchial gene-expression effects of tobacco smoking in people living with HIV
Many of the effects of smoking on bronchial gene expression are shared between PLWH and non-HIV individuals. Of the subset of genes that differ between PLWH and non-HIV individuals, it appears that the effect of smoking on gene expression is more attenuated in PLWH. This includes genes related to oxidative stress and epithelial integrity, and suggests potential mechanisms that may contribute to smoking-related outcomes that are more prevalent in PLWH, such as lung cancer.
Authors
- R. Taylor Pickering (ORCID: https://orcid.org/0000-0002-5243-4068)
- M. E. Lenburg
- Dena Kivett
- Michael H. Ieong (ORCID: https://orcid.org/0000-0003-4723-9556)
- Minyi Lee (ORCID: https://orcid.org/0000-0003-3814-9890)
- Nina Lin (ORCID: https://orcid.org/0000-0001-8362-3649)
- Xiaohui Xiao
- Alex Olson
- Archana Asundi
- Samantha Roche
- Gang Liu
Institutions
- Boston University (US)
- Boston Medical Center (US)
Publication Details
- Journal
- JAIDS Journal of Acquired Immune Deficiency Syndromes
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1097/qai.0000000000003853
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- GlaxoSmithKline
- Gilead Sciences
- ViiV Healthcare
- National Institutes of Health
- Center for AIDS Research, University of Washington
- National Institute on Drug Abuse
- National Cancer Institute