Gluteal adipose-derived stem cell exosomes promote macrophage polarization and cartilage regeneration in osteoarthritis via PTPRC modulation
Gluteal ADSC-Exo exert potent anti-inflammatory and chondroprotective effects through immunometabolic reprogramming of macrophages, with PTPRC identified as a key mediator, supporting their translational potential for OA therapy.
Authors
- Iat-Hang Fong (ORCID: https://orcid.org/0000-0002-8235-0877)
- Kuang-Tai Kuo (ORCID: https://orcid.org/0000-0003-2754-2283)
- Vijesh Kumar Yadav (ORCID: https://orcid.org/0000-0002-2679-1205)
- K T. Chen
- Narpati Wesa Pikatan (ORCID: https://orcid.org/0000-0002-2149-325X)
- Yen-Shuo Chiu
- Chi-Chang Huang
Institutions
- Universitas Gadjah Mada (ID)
- Taipei Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
- National Taiwan Sport University (TW)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1016/j.biopha.2026.119130
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00