Miltirone promotes pyroptosis via increasing pyroptosis-related protein NLRP3 and AIM2 in kidney renal clear cell carcinoma
Our study revealed the prognostic value of NLRP3 and AIM2 in KIRC. Miltirone treatment inhibited KIRC cell proliferation and enhanced cell pyroptosis via the NLRP3/AIM2/GSDMD axis. This study provides a novel molecular mechanism and potential therapeutic targets in KIRC progression.
Authors
- Pingli He
- Tao Huang (ORCID: https://orcid.org/0000-0002-3438-9654)
- Yuan Wang (ORCID: https://orcid.org/0000-0001-9189-3630)
- Chen Guo (ORCID: https://orcid.org/0009-0003-5029-3657)
- Jinzhen Cai
- Lixia Song
- Qinghai Wang
- Yang Gao
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fimmu.2026.1702901
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00