Sex Differences in Amyloid Pathology by Race, Ancestry, and Apolipoprotein E ε4 in an Admixed Autopsy Sample
The findings indicate that female sex, APOEε4, and both race and African ancestry were jointly associated with amyloid in this study population. Excess amyloid among women may partly explain their greater tau burden and steeper cognitive decline. These findings highlight the importance of incorporating sex, race, and ancestry into biomarker thresholds, risk stratification, and the design of preventive or disease-modifying trials for Alzheimer disease.
Authors
- Renata Elaine Paraízo Leite (ORCID: https://orcid.org/0000-0002-5878-398X)
- Vítor Ribeiro Paes (ORCID: https://orcid.org/0000-0001-8752-5624)
- Isabel Elaine Allen (ORCID: https://orcid.org/0000-0001-9029-9744)
- Eduardo Ferriolli
- Michel Satya Naslavsky
- Roberta Diehl Rodriguez
- Maison Abu Raya
- R. Nitrini
- Renaud La Joie
- Carlos Augusto Pasqualucci
- Claudia Kimie Suemoto
- Lea T. Grinberg
Institutions
- Universidade de São Paulo (BR)
- University of California, San Francisco (US)
- Jacksonville College (US)
- University Memory and Aging Center (US)
- Global Brain Health Institute (US)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1001/jamaneurol.2026.0054
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00