Herpes Simplex Virus Type 1 Encephalitis: A Prospective Population-Based Cohort Study

Early recognition of HSV-1 encephalitis remains challenging, and the condition is associated with high mortality. Delayed acyclovir treatment, especially following lumbar puncture, was associated with increased risks of fatal outcome.

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Publication Details

Journal
Clinical Infectious Diseases
Published
2026-02-22
DOI
https://doi.org/10.1093/cid/ciag136
Primary Topic
Herpesvirus Infections and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Herpes Simplex Virus Type 1 Encephalitis: A Prospective Population-Based Cohort Study

Lærke Storgaard Duerlund, Henrik Nielsen, Christian Brandt, Micha Phill Grønholm Jepsen et al.
Clinical Infectious Diseases
Herpesvirus Infections and Treatments
article

Herpes Simplex Virus Type 1 Encephalitis: A Prospective Population-Based Cohort Study

Lærke Storgaard Duerlund, Henrik Nielsen, Christian Brandt, Micha Phill Grønholm Jepsen, Birgitte Rønde Hansen, Jacob Bodilsen, Merete Storgaard, Lykke Larsen, Arun Venkatesan, Morten Blaabjerg, Helene Mens, Hans Rudolf Lüttichau, Christian Østergaard Andersen, Lothar Wiese, the DASGIB study group
article en

Abstract

Early recognition of HSV-1 encephalitis remains challenging, and the condition is associated with high mortality. Delayed acyclovir treatment, especially following lumbar puncture, was associated with increased risks of fatal outcome.

Clinical Infectious Diseases
Statens Serum Institut (DK), Roskilde University (DK), Johns Hopkins University (US), Roskilde Sygehus (DK), Johns Hopkins Medicine (US), Aalborg University Hospital (DK), Odense University Hospital (DK), Herlev Hospital (DK), Hvidovre Hospital (DK), Aarhus University Hospital (DK), Copenhagen University Hospital (DK), Gentofte Hospital (DK), Rigshospitalet (DK), European Society of Clinical Microbiology and Infectious Diseases (CH), Pulmonary Associates (US), Aalborg University (DK)
Good health and well-being
Openalex Percentile: Top 46%
Herpesvirus Infections and Treatments
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