Lower Limit of Normal of Pulmonary Function to Define Baseline Lung Allograft Dysfunction
BLAD defined by concurrent baseline FEV1 or FVC below the LLN was strongly associated with increased risk of graft loss. These findings extend prior studies that used the fixed 80% threshold by demonstrating that an LLN-based, age- and sex-adjusted definition of BLAD identifies lung transplant recipients at risk, thereby avoiding fixed cutoff associated age- and sex-bias.
Authors
- Susanne Simon (ORCID: https://orcid.org/0009-0000-8532-9427)
- Jürgen Barton
- Carlo Mümmler (ORCID: https://orcid.org/0000-0002-2501-3356)
- Michael Gerckens (ORCID: https://orcid.org/0000-0002-2251-4382)
- N. Kneidinger
- Paola Arnold
- AÖ Yildirim (ORCID: https://orcid.org/0000-0001-6340-3884)
- Jürgen Behr
- Jens Gottlieb
Institutions
- Medical University of Graz (AT)
- LMU Klinikum (DE)
- Medizinische Hochschule Hannover (DE)
- German Center for Lung Research (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1097/txd.0000000000001913
- Primary Topic
- Transplantation: Methods and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00