A meta-analysis of potential genetic factors associated with antipsychotic-induced weight gain in adults with severe mental illness
The study identified six SNPs that predispose adult individuals to AIWG, with <i>HTR2C rs3813929</i> and <i>ADRA2A rs1800544</i> showing the largest effect sizes. Five of these have a role in hypothalamic regulation of appetite/satiety. Identification of these risk-associated SNPs may assist the development of a polygene/polyphenotypic risk score to identify individuals with psychosis who are at heightened risk of experiencing AIWG.
Authors
- Gavin P. Reynolds (ORCID: https://orcid.org/0000-0001-9026-7726)
- Adam Jameson (ORCID: https://orcid.org/0000-0002-3248-2302)
- Mark Shakespeare
- Y. A. Illangasekera (ORCID: https://orcid.org/0000-0002-7466-5502)
- Adrian Hugh Heald (ORCID: https://orcid.org/0000-0002-9537-4050)
- Camila Marcelino Loureiro (ORCID: https://orcid.org/0000-0002-0239-5064)
- John Warner‐Levy (ORCID: https://orcid.org/0000-0003-2632-7266)
- Lleyton Belston (ORCID: https://orcid.org/0009-0001-0094-1949)
- Loren Wilkins
- Cheyenne Meehan
- Caroline F. Dalton
- Sushant Saluja
Institutions
- University of Bradford (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Humber Teaching NHS Foundation Trust (GB)
- Salford Royal Hospital (GB)
- Sheffield Hallam University (GB)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1177/02698811261416080
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00