A multifaceted interplay between hemophagocytosis, IL‐18 and type I IFN distinguishes Still disease from other autoinflammatory diseases
This unprecedented large omics dataset of SAIDs, revealed that complex interactions between hemophagocytosis, IL-18 and type I IFN signaling characterize SD. Furthermore, two distinct subgroups in SD patients are distinguished by the degree of hemophagocytic activity. Finally, the large proteomics and RNAseq datasets generated in this study can serve as an invaluable resource for the further investigation SD and other SAIDs.
Authors
- Laurie Vaillant
- Iris van Zuijen
- Yvonne M. Mueller (ORCID: https://orcid.org/0000-0002-4654-7509)
- Katerina Laskari (ORCID: https://orcid.org/0000-0002-6477-6583)
- Robert J. Dekker
- Sharon Veenbergen (ORCID: https://orcid.org/0009-0009-9114-2998)
- Fanny Coffin
- Stefan J. Erkeland (ORCID: https://orcid.org/0000-0002-1019-7957)
- Eric M. Bindels (ORCID: https://orcid.org/0000-0001-9502-669X)
- Peter D. Katsikis
- Dwin G. B. Grashof
- Yvan Jamilloux
- Cem Gabay
- Vassili Soumelis
- Harmen J G van de Werken
- Bruno Fautrel
- Charlotte Girard
Institutions
- Université Claude Bernard Lyon 1 (FR)
- University of Geneva (CH)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Erasmus MC (NL)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Pitié-Salpêtrière Hospital (FR)
- Athens State University (US)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1002/art.70102
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00