HIF1α reinforces PPARγ-dependent metabolic rechanneling to support lipid accumulation in adipocytes
Together, these findings provide metabolic and enzymatic validations of a late-stage, state-dependent HIF1α-PPARγ lipid storage program and implicate the glycerol-3-phosphate dehydrogenase 1 (GPD1)-glycerol-3-phosphate acyltransferase (GPAT) axis as a key molecular executor of hypertrophic lipid accumulation in differentiated adipocytes.
Authors
- Arka Provo Das
- Ting Yuan (ORCID: https://orcid.org/0000-0001-6098-8733)
- Chaonan Zhu (ORCID: https://orcid.org/0000-0002-8337-8484)
- Peter Mirtschink (ORCID: https://orcid.org/0000-0001-5832-1673)
- Meiqian Wu
- J Krishnan
- M Pham
- Yijie Mao
- Yue Wang
Institutions
- Goethe University Frankfurt (DE)
- Goethe-Institute United Kingdom (GB)
- German Centre for Cardiovascular Research (DE)
- University Hospital Carl Gustav Carus (DE)
Publication Details
- Journal
- Frontiers in Molecular Medicine
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fmmed.2026.1716464
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00