From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce

International guidelines define standards of care for type 2 diabetes (T2D), obesity, cardiovascular disease (CVD), metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD). Yet implementation at the national level remains inconsistent, leading to persistent gaps between evidence-based recommendations and real-world practice. Key barriers include linguistic and cultural adaptation, limited communication to clinicians, and siloed regulatory and reimbursement processes. Addressing these challenges requires coordinated strategies, such as concise translations, digital platforms and decision-support tools, integration into medical education, and structured monitoring and evaluation frameworks with feedback and incentives. Equitable and sustainable access further depends on coordination between medical societies, governmental authorities, payers, and patient representatives. Evidence from existing initiatives shows that systematic, context-sensitive approaches can measurably improve care. Building on these lessons, this Commentary recommends priorities for national implementation to ensure that guidelines move more effectively from publication to practice and realise their full potential to improve patient outcomes.

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Publication Details

Journal
Cardiovascular Diabetology
Published
2026-02-23
DOI
https://doi.org/10.1186/s12933-026-03098-z
Citations
1
Primary Topic
Clinical practice guidelines implementation
Type
article
Field-Weighted Citation Impact
41.85

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article

From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce

Prashant Nedungadi, Christopher G. Parkin, Monika Kellerer, Katharine Barnard‐Kelly et al.
1 citations
Cardiovascular Diabetology
Clinical practice guidelines implementation
41.85
article

From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce

Prashant Nedungadi, Christopher G. Parkin, Monika Kellerer, Katharine Barnard‐Kelly, MATTHIAS BLÜHER, Luca Busetto, N. Marx, Helena N. Boll, Nebojsa M. Lalic, Lars Rydén, Eberhard Standl, Antonio Ceriello, F Cosentino, Frank C. Brosius, Frank Tacke, Oliver Schnell, Sue Koob, Tadej Battelino, Wayne Huey-Herng Sheu, James R. Gavin, Banshi Saboo, Jennifer Green, Linong Ji, Christoph Wanner, Pinar Topsever
article en
1 citations

Abstract

International guidelines define standards of care for type 2 diabetes (T2D), obesity, cardiovascular disease (CVD), metabolic dysfunction-associated steatotic liver disease (MASLD) and chronic kidney disease (CKD). Yet implementation at the national level remains inconsistent, leading to persistent gaps between evidence-based recommendations and real-world practice. Key barriers include linguistic and cultural adaptation, limited communication to clinicians, and siloed regulatory and reimbursement processes. Addressing these challenges requires coordinated strategies, such as concise translations, digital platforms and decision-support tools, integration into medical education, and structured monitoring and evaluation frameworks with feedback and incentives. Equitable and sustainable access further depends on coordination between medical societies, governmental authorities, payers, and patient representatives. Evidence from existing initiatives shows that systematic, context-sensitive approaches can measurably improve care. Building on these lessons, this Commentary recommends priorities for national implementation to ensure that guidelines move more effectively from publication to practice and realise their full potential to improve patient outcomes.

Cardiovascular DiabetologyVol. 25(1)
American Heart Association (US), nLIGHT (United States) (US), Karolinska University Hospital (SE), Helmholtz Centre for Environmental Research (DE), University of Arizona (US), University of Padua (IT), Emory University (US), University of Ljubljana (SI), National Health Research Institutes (TW), Peking University (CN), Ljubljana University Medical Centre (SI), Southern Health NHS Foundation Trust (GB), Helmholtz Zentrum München (DE), University of Belgrade (RS), Clinical Research Institute (US), MultiMedica (IT), India Diabetes Research Foundation (IN), Marienhospital Stuttgart (DE), Universitätsklinikum Aachen (DE), Peking University People's Hospital (CN), University Hospital Leipzig (DE), Duke Medical Center (US), Universitätsklinikum Würzburg (DE), Bangalore Diabetes Centre (IN), Diabetes Care & Hormone Clinic (IN), Kent Hastanesi (TR), Acıbadem Adana Hospital (TR), University of Bari Aldo Moro (IT), Charité - Universitätsmedizin Berlin (DE), RWTH Aachen University (DE)
Amgen, Eli Lilly and Company, AstraZeneca, Bayer, Sanofi, Dexcom, Novo Nordisk, Roche Diabetes Care, Abbott Diabetes Care, Daiichi Sankyo Europe
Partnerships for the goals
Openalex Percentile: Top 0%
Clinical practice guidelines implementation
41.85
DOIOpen Access PDFOpenAlex
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