Mechanisms of fosfomycin resistance observed in clinical isolates of <i>Escherichia coli</i> from Canada: CANWARD 2007–2022
In Canada, the occurrence of mobile fosfomycin resistance determinants (<i>fosA</i> genes) in clinical isolates of <i>E. coli</i> is low (∼0.14% of all isolates). Our results highlight the importance of the functional transporter systems GlpT and UhpT for the <i>in vitro</i> activity of fosfomycin.
Authors
- Nicole A. Lerminiaux (ORCID: https://orcid.org/0000-0001-7914-9198)
- Laura F. Mataseje (ORCID: https://orcid.org/0000-0002-8014-1107)
- George Zhanel
- Melanie R. Baxter
- Cole Lysak
- James A Karlowsky
Institutions
- Public Health Agency of Canada (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/jacamr/dlag020
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00