Chaihu-Baishao confers antidepressant effects in CSDS mice by ameliorating hippocampal synaptic plasticity impairment via blocking α2δ-1-NR2B interaction
The findings of this study elucidate a novel mechanism through which CB exerts its antidepressant effects, specifically by modulating the α2δ-1-NR2B interaction and restoring of synaptic plasticity within the hippocampus.
Authors
- Suhua Zang
- Yuxuan Zhang (ORCID: https://orcid.org/0000-0001-9407-9589)
- Yuxing Wang (ORCID: https://orcid.org/0000-0003-3079-5572)
- Depei Li
- Chaonan Wang
- Lingchen Hou
- Feiyu An
- Yuanyuan Zhang
- Ziyun Ban
- Yunyun Geng
- Yonggang Gao
- Yuqi Liu
Institutions
- Hebei University of Chinese Medicine (CN)
- University of Missouri (US)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1016/j.jep.2026.121427
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00