Radiomic Features Extracted from Magnetic Resonance Imaging to Identify Arteriopathy in a Humanized Mouse Model of Sickle Cell Anemia and Sickle Cell Trait
This study demonstrates feasibility of radiomics in discriminating arterial features between SCD and control mice, and supports radiomics as a non-invasive imaging analytical approach to characterize arterial remodeling in preclinical SCD models, motivating future translational studies linking imaging features to vascular pathology.
Authors
- Albert Comelli (ORCID: https://orcid.org/0000-0002-9290-6103)
- Viviana Benfante (ORCID: https://orcid.org/0000-0002-3629-355X)
- H. Lee
- Manu O. Platt (ORCID: https://orcid.org/0000-0001-6390-4320)
- Liana Hatoum
- Edward A. Botchwey
Institutions
- National Institutes of Health (US)
- Georgia Institute of Technology (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Center for Information Technology (US)
- National Institute of Biomedical Imaging and Bioengineering (US)
- Ri.MED (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1007/s10439-026-04034-8
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health