Comparative Effectiveness and Safety of LAMA-LABA Inhalers in Chronic Obstructive Pulmonary Disease
This cohort study found that umeclidinium-vilanterol was associated with improved clinical outcomes compared with glycopyrrolate-formoterol and tiotropium-olodaterol. Patients, prescribers, and health systems may consider once-daily umeclidinium-vilanterol dry powder inhalers over alternatives among new users of LAMA-LABA therapy.
Authors
- S. J. Bame
- Shirley Wang (ORCID: https://orcid.org/0000-0001-7761-7090)
- Gerard Portela (ORCID: https://orcid.org/0000-0002-1871-6117)
- Samy Suissa
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- Jewish General Hospital (CA)
Publication Details
- Journal
- JAMA Internal Medicine
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1001/jamainternmed.2025.8087
- Primary Topic
- Inhalation and Respiratory Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00