TAAR1-mediated pathways regulating nigrostriatal function and the discovery and pharmacological characterization of a novel TAAR1 agonist, Selutaront
This study demonstrates that TAAR1 regulates nigrostriatal function primarily via the PKA/CREB/DARPP32 signaling axis. Selutaront, a novel highly selective TAAR1 agonist with favorable drug-like properties, represents a promising candidate for schizophrenia treatment and provides mechanistic insights into TAAR1-targeted therapy.
Authors
- Jingwei Tian (ORCID: https://orcid.org/0009-0005-7930-0018)
- Xuan Deng
- W WANG (ORCID: https://orcid.org/0009-0007-7992-8125)
- Yangping Wang (ORCID: https://orcid.org/0000-0002-6226-0460)
- Hui Lei
- Jianzhao Zhang
- Jiawei Lv
- Jing Lu
- Lin Wang
Institutions
- Yantai University (CN)
- Ministry of Education (KR)
- Luye Pharma (China) (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fphar.2026.1759454
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yantai University