Linezolid‐induced lactic acidosis in critically ill patients: A multicentre study of incidence, severity and predictors
Linezolid-associated lactic acidosis is a frequent and often severe complication in ICU patients, typically developing early during therapy. Sepsis, non-pneumonia infections and norepinephrine use were identified as key risk factors. These findings highlight the need for early recognition and vigilant monitoring of high-risk patients to promote safer use of linezolid in critically ill populations.
Authors
- Lina Naseralallah (ORCID: https://orcid.org/0000-0003-3035-1357)
- Somaya Koraysh (ORCID: https://orcid.org/0000-0002-2743-4496)
- Khaled Aboujabal (ORCID: https://orcid.org/0000-0003-1448-2381)
- Bodoor Aboujabal (ORCID: https://orcid.org/0000-0001-9026-885X)
- Zahra Noureddine (ORCID: https://orcid.org/0000-0001-9695-7293)
Institutions
- Hamad General Hospital (QA)
- Hamad Medical Corporation (QA)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-02-22
- DOI
- https://doi.org/10.1002/bcp.70496
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00