Association analysis of the differences in intestinal flora and clinical tumor indicators among colorectal cancer patients

The intestinal flora of CRC patients is characterized by decreased diversity, an enrichment of pathogenic bacteria, and a reduction in protective flora. these microbial alterations are associated with tumor progression, potentially via inflammatory and metabolic pathways, although causal mechanisms remain to be functionally validated. The flora health index and dysbiosis index have potential for use as adjunctive diagnostic tools. However, individualized preventive intervention strategies need to be developed in the future by combining multi-omics data.