Preservation of circulatory death donor Rat hearts using hemoglobin-based oxygen carriers for normothermic machine perfusion: enhancing viability and functionality
These findings indicate that HBOC <i>ex vivo</i> perfusion exerts dual cytoprotective effects by limiting ischemic injury through optimized oxygen delivery and attenuating reperfusion-associated injury cascades via antioxidant and anti-inflammatory mechanisms. EVHP with HBOC represents a promising preservation strategy for DCD hearts, with the potential to reduce myocardial IRI and improve post-transplant cardiac function in marginal donor hearts.
Authors
- Xiangmeng Wang (ORCID: https://orcid.org/0000-0003-3643-3353)
- Peitao Zhou (ORCID: https://orcid.org/0000-0001-5094-3945)
- Zekai Huang (ORCID: https://orcid.org/0000-0002-4571-7086)
- Jianqiang Ji
- Zhong Zhang (ORCID: https://orcid.org/0000-0002-5605-4951)
- Jun Lu (ORCID: https://orcid.org/0000-0002-9878-9091)
- Shaoyi Zheng
- Liwei Xu
- Chuangjie Niu
- Xuan Pan
Institutions
- Shantou University (CN)
- Yue Bei People's Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fcvm.2026.1712642
- Primary Topic
- Hemoglobin structure and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province