Bacterial co-detection is associated with higher multidrug-resistant <i>Pseudomonas aeruginosa</i> risk: insights from the MIMIC-IV database and metagenomic analysis
Our findings indicate that bacterial co-detection with PA elevates the risk of MDR-PA and worsens clinical outcomes, potentially driven by HGT-mediated ARG exchange within the host microbiota.
Authors
- Zheying Tao
- B.W. Zhang
- Xiaoling Qi
- Jialin Liu (ORCID: https://orcid.org/0000-0001-6625-3076)
- Na Pei
- Xiaoli Wang
- Li Zhang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Mental Health Center (CN)
- Botswana Geoscience Institute (BW)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1093/jacamr/dlag023
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00