ElectroChemputer with integrated monitoring for programmable electrochemistry

<h2>Summary</h2> Electrochemical synthesis offers a sustainable and atom-economical alternative to conventional methods. Although recent advances have enabled electrochemical discovery, the integration of real-time control with analysis promises to allow electrochemical "fly by wire." Herein, we present the ElectroChemputer, a programmable, modular standard platform enabling fully automated execution of electrochemical workflows. It integrates nuclear magnetic resonance (NMR) spectroscopy and electroanalytical reaction monitoring to provide structural and quantitative insight into reaction progression. Across 170 h of runtime, the system accumulated >1,500 coordinated unit operations and acquired >600 cyclic voltammograms. The ElectroChemputer enabled real-time stopped-flow NMR monitoring and data analysis of complex processes, such as decarboxylation via alternating polarity. Furthermore, we explored its flexibility for diverse transformations, including nucleophilic substitutions, oxidative couplings, and electrodepositions. By using queues and blueprints, it could run multiple protocols in parallel, demonstrating its adaptability across reaction classes, electrode materials, and configurations. Through its modular architecture, the ElectroChemputer sets the stage for programmable, autonomous, and democratized electrochemical synthesis.