Cystathionine Enzymes in Transsulfuration and HO-1 Production: Impact on Spermatogenic Disorders in Folate and B12 Deficient Mice.
Deficiencies in folate and vitamin B12 negatively affect sperm quality and testicular function in male mice, likely through disrupted homocysteine metabolism and altered gene expression in the trans-sulfuration pathway. These findings underscore the importance of adequate B-vitamin intake for male reproductive health.
Authors
- Farzaneh Rabiee
- Nafise Zamani (ORCID: https://orcid.org/0000-0003-1508-2486)
- Zahra Mohammadi (ORCID: https://orcid.org/0000-0001-8797-2184)
- Marziyeh Tavalaee (ORCID: https://orcid.org/0000-0001-9954-964X)
- Mohammad Hossein Nasr-Esfahani
Institutions
- Royan Institute (IR)
- Kerman University of Medical Sciences (IR)
- Academic Center for Education, Culture and Research (IR)
Publication Details
- Journal
- PubMed
- Published
- 2026-02-22
- DOI
- https://doi.org/10.22074/cellj.2026.2057175.1822
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00