Clinical outcomes and survival in patients with NSCLC and EGFR exon 20 mutations: evidence from real-world clinical practice in a retrospective study in Galicia

The results show the limited effectiveness of TKIs in patients with EGFR Ex20Ins and highlight the need for specific therapies. Platinum-based chemotherapy performed better in preventing disease relapse.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-02-23
DOI
https://doi.org/10.3389/fonc.2026.1677766
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
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article

Clinical outcomes and survival in patients with NSCLC and EGFR exon 20 mutations: evidence from real-world clinical practice in a retrospective study in Galicia

Lucía Santomé Couto, Martín Emilio Lázaro Quintela, Francisco Javier Afonso Afonso, Manuel Fernández-Bruno et al.
Frontiers in Oncology
Lung Cancer Treatments and Mutations
article

Clinical outcomes and survival in patients with NSCLC and EGFR exon 20 mutations: evidence from real-world clinical practice in a retrospective study in Galicia

Lucía Santomé Couto, Martín Emilio Lázaro Quintela, Francisco Javier Afonso Afonso, Manuel Fernández-Bruno, Cristina Azpitarte Raposeiras, Natalia Fernández Núñez, Ma Carmen Areses Manrique, Raquel Romero Van der Schoot, Jorge García-González
article en

Abstract

The results show the limited effectiveness of TKIs in patients with EGFR Ex20Ins and highlight the need for specific therapies. Platinum-based chemotherapy performed better in preventing disease relapse.

Frontiers in OncologyVol. 16
Universidade da Coruña (ES), University Hospital Complex Of Vigo (ES), Povisa Hospital (ES), Hospital Universitario Lucus Augusti (ES), Instituto de Investigación Sanitaria de Santiago (ES), Complejo Hospitalario de Pontevedra (ES), Medical Research Network (US), Complejo Hospitalario de Ourense (ES)
Good health and well-being
Openalex Percentile: Top 45%
Lung Cancer Treatments and Mutations
DOIOpen Access PDFOpenAlex
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