Prevalence of HER2-ultralow breast cancer in South Korea: a multicenter study by reassessment of HER2-zero cases
Approximately 40% of cases initially categorized as IHC 0 were reclassified as HER2-ultralow. The substantial inter-institutional variability observed in interpreting low-level HER2 expression highlights the need for standardized training and quality assurance to ensure accurate identification of patients eligible for HER2-targeted antibody-drug conjugates.
Authors
- Chungyeul Kim (ORCID: https://orcid.org/0000-0002-9636-5228)
- Gyungyub Gong (ORCID: https://orcid.org/0000-0001-5743-0712)
- So Dug Lim (ORCID: https://orcid.org/0000-0003-2036-0313)
- Sun‐Young Jun (ORCID: https://orcid.org/0000-0002-3007-2094)
- Min Chong Kim (ORCID: https://orcid.org/0000-0003-2798-863X)
- Young Kyung Bae (ORCID: https://orcid.org/0000-0002-6689-9413)
- So Mang Lee
- Ji Shin Lee
- Jeong Yun Shim
- Jee Yeon Kim
- E. Cho
- Ji-Young Kim
- Ahrong Kim
- Hye Jeong Choi
- Hee Jin Lee
Institutions
- Ulsan College (KR)
- Konkuk University (KR)
- Korea University Medical Center (KR)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- University of Ulsan (KR)
- Chonnam National University Hospital (KR)
- The Catholic University of Korea Incheon St. Mary's Hospital (KR)
- Pusan National University Hospital (KR)
- Ulsan University Hospital (KR)
- CHA University (KR)
- Pusan National University Yangsan Hospital (KR)
- Yeungnam University Medical Center (KR)
- CHA University Gangnam Medical Center (KR)
- Yeungnam University College
- Yeungnam University (KR)
- Sungkyunkwan University (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Journal of Pathology and Translational Medicine
- Published
- 2026-02-23
- DOI
- https://doi.org/10.4132/jptm.2025.10.22
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00