Feasibility Study of Decellularized Corneal Lenticule in a Porcine Model for Macular Hole Closure

Our preliminary results suggest that decellularized hCLs can be successfully implanted to close FTMHs in our preclinical ex vivo model of study, paving the way for future research into bioengineered hCLs for therapeutic purposes.

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Publication Details

Journal
Ophthalmology and Therapy
Published
2026-02-23
DOI
https://doi.org/10.1007/s40123-026-01333-0
Primary Topic
Retinal and Macular Surgery
Type
article
Field-Weighted Citation Impact
0.00
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article

Feasibility Study of Decellularized Corneal Lenticule in a Porcine Model for Macular Hole Closure

Domitilla Mandatori, Mario Nubile, Alessia Lamolinara, Nadia Di Pietrantonio et al.
Ophthalmology and Therapy
Retinal and Macular Surgery
article

Feasibility Study of Decellularized Corneal Lenticule in a Porcine Model for Macular Hole Closure

Domitilla Mandatori, Mario Nubile, Alessia Lamolinara, Nadia Di Pietrantonio, Assunta Pandolfi, Marcello Allegretti, Letizia Pelusi, F Del Pizzo, Samuele Faieta, Maria Ludovica Ruggeri, Alberto Quarta, Rodolfo Mastropasqua, Leonardo Mastropasqua
article en

Abstract

Our preliminary results suggest that decellularized hCLs can be successfully implanted to close FTMHs in our preclinical ex vivo model of study, paving the way for future research into bioengineered hCLs for therapeutic purposes.

Ophthalmology and Therapy
University of Chieti-Pescara (IT), Dompé (Italy) (IT)
Openalex Percentile: Top 47%
Retinal and Macular Surgery
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