Construction and validation of a nutritional status (CONUT)-based nomogram for predicting prolonged hematological toxicity in relapsed/refractory multiple myeloma after CAR-T cell therapy
We developed a validated nomogram that incorporates the baseline CONUT score and key clinical variables (e.g., tumor burden, ferritin, IFN-γ) to effectively predict PHT risk in R/R MM patients after CAR-T cell therapy, thereby facilitating early risk stratification and guiding personalized management.
Authors
- Qing-Yun Wu
- Qiwen Feng
- Xin-Ying Duan
- Kunming Qi
- Huan-Xin Zhang (ORCID: https://orcid.org/0000-0002-2312-3762)
- Yawen Wang (ORCID: https://orcid.org/0000-0003-4876-1207)
- Yang Liu
- Zhen-Yu Li
- Peng Xu
Institutions
- Jiangsu Normal University (CN)
- Xuzhou Medical College (CN)
- Affiliated Hospital of Xuzhou Medical College (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fnut.2026.1729151
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Xuzhou Medical University