GCDCA promotes hepatocellular carcinoma progression through S1PR2/PI3K/AKT-mediated polarization of M2-type macrophages
This study demonstrates that GCDCA drives HCC progression by inducing M2-type macrophage polarization via the S1PR2/PI3K/AKT signaling pathway, which subsequently enhances tumor cell stemness. These findings elucidate a novel mechanism by which bile acids remodel the TME to promote liver cancer, highlighting potential therapeutic targets within this pathway.
Authors
- Min Tao (ORCID: https://orcid.org/0000-0002-7221-6084)
- Wei Yu (ORCID: https://orcid.org/0000-0001-6817-9076)
- Kuizhi Zhang
- Haixin Yan
- Hengyan Zhang
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Simin Lu
- Mengmeng Xue
- Li Zhang
- Lixin Wei
- Gang Lv
- Luyao Zhang
- Lu Gao
Institutions
- Second Military Medical University (CN)
- Anhui Medical University (CN)
- Chinese General Hospital College of Nursing and Liberal Arts (PH)
- National Center for Tumor Diseases (DE)
- Changhai Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Fourth Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fimmu.2026.1640450
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00