Novel immune-related susceptibility loci associated with pediatric steroid-sensitive nephrotic syndrome identified by a transethnic genome-wide association study
We identified two novel immune-related loci associated with susceptibility to SSNS, nominating M6PR and ORMDL3 as potential contributors to SSNS risk in a cell-type-specific manner, and confirmed the association of PRS with earlier disease onset. These findings expand our knowledge of the genetic architecture of SSNS and highlight the importance of large-scale collaborations in uncovering genetic associations related to SSNS.
Authors
- Jingjing Cui
- Xiting Li (ORCID: https://orcid.org/0009-0005-9906-3208)
- Xuejun Yang
- Rui Liang
- Mengdi Wang (ORCID: https://orcid.org/0000-0002-2101-9507)
- Zijian Tian
- Jia Jiao
- X Yang
- Junli Wan
- Xiaojie Gao
- Kaixin Zhou
- Han Chan
- Qin Yang
- Fenfen Ni
- Baohui Yang
- Xueting Chen
- Qiu Li
- Anshuo Wang
- Haiping Yang
- Shipin Feng
- Xuelan Chen
- Bo Zhao
- Gaofu Zhang
- Li Wang
- Jian Shao
- Daoqi Wu
Institutions
- Chengdu Women's and Children's Central Hospital (CN)
- Kunming Children's Hospital (CN)
- Key Laboratory of Guangdong Province (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen Children's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- University of Chinese Academy of Sciences (CN)
- Chongqing Medical University (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Nephrology Dialysis Transplantation
- Published
- 2026-02-22
- DOI
- https://doi.org/10.1093/ndt/gfag041
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00