Clinical and molecular characteristics, antibiotic susceptibility, risk factors and predictors of mortality in carbapenem-resistant klebsiella pneumoniae bloodstream infections in Southern Sichuan, China: a 5-year multicenter study
Carbapenem-resistant Klebsiella pneumoniae (CRKP) in southern Sichuan, China, is characterized by high resistance rates, the continuous emergence of novel clones, and elevated patient mortality. These findings underscore the urgent need for enhanced surveillance that integrates clinical and molecular epidemiology with targeted interventions. This study provides a robust scientific foundation for optimizing the clinical management of CRKP bloodstream infections. This study provides a scientific basis for optimizing clinical management strategies for CRKP-BSI.
Authors
- Zixiang Luo (ORCID: https://orcid.org/0000-0002-4445-7286)
- Yueshuai Wei (ORCID: https://orcid.org/0009-0009-0549-8374)
- Chenghong Gu (ORCID: https://orcid.org/0000-0002-3306-767X)
- Jiayi Liu (ORCID: https://orcid.org/0000-0003-1819-2998)
- Jie Deng (ORCID: https://orcid.org/0000-0002-2181-2273)
- Yanzhi Li
- Wenchao Xie
- Zhangrui Zeng
- Yuan Jiang
- Yuling Yang
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- The Fourth People's Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Neijiang Normal University (CN)
- Science and Technology Department of Sichuan Province (CN)
- Zigong First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fcimb.2026.1741170
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 21.79
Funders
- Southwest Medical University