Generation and characterization of human induced pluripotent stem cells from neuropathologically confirmed multiple system atrophy patient-derived fibroblasts
We have created a robust and valuable iPSC collection aimed at correlating the <i>in vivo</i> confirmed clinical and pathological variants with the <i>in vitro</i> phenotypes. This unique tool can contribute to the understanding of MSA pathophysiology, the discovery of therapeutic targets, and the development of therapeutic screening approaches.
Authors
- Wouter Peelaerts (ORCID: https://orcid.org/0000-0003-3776-4162)
- Jacqueline Severino (ORCID: https://orcid.org/0000-0001-6959-0342)
- Dory Cohen
- Manel Fernández (ORCID: https://orcid.org/0000-0002-8558-9920)
- Adrià Dangla-Valls (ORCID: https://orcid.org/0000-0002-3131-3195)
- Yarko Compta
- Veerle Baekelandt (ORCID: https://orcid.org/0000-0001-8966-2921)
- Alexandra Pérez-Soriano
- Maria J. Martí
- Martín Gigirey-Suárez
- Ruben Fernandez-Santiago
- Ronald Melki
- Laura Batlle-Morera
- Mireia Alemany-Ribes
- Mario Ezquerra
- Almudena Santos
Institutions
- Allen Institute for Brain Science (US)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Advanced Pharma (US)
- Direction de la Recherche Fondamentale (FR)
- Centre for Genomic Regulation (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fimmu.2026.1641981
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00