A novel TGFβ1–Hs3st2–tau axis regulates tau pathology and synaptic integrity
These findings define a new TGFβ1-<i>Hs3st2</i>-tau axis in the hippocampus and highlight 3S-HS as a key modulator of tau pathology and synaptic dysfunction. Targeting this pathway may offer new therapeutic opportunities in tauopathies and related neurodegenerative disorders.
Authors
- Heloise Merrick
- Xavier Laffray (ORCID: https://orcid.org/0000-0001-5917-9154)
- Dulce Papy-Garcia
- Martin Diener
- Mohand Ouidir Ouidja
- Minh Bao Huynh
- Ajitha Thuraisamy
- Sethupathiraj Selvaraj
- Rafael Castillo-Negrete
- Peter Jedlicka
Institutions
- Goethe University Frankfurt (DE)
- Université Paris-Est Créteil (FR)
- Justus-Liebig-Universität Gießen (DE)
- Translational Research in Oncology (FR)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fnins.2025.1726022
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00