Cellular signaling pathway of Shiga toxin-induced ATP release
Stx interaction with HeLa cells initiates a signaling pathway involving membrane G protein, PI3K, phospholipase C and IP<sub>3</sub>R, ultimately leading to ATP release and promoting cytotoxic effects. The PI3K inhibitor alpelisib altered PIP2 expression in Stx2-challenged mice.
Authors
- Diana Karpman (ORCID: https://orcid.org/0000-0001-7220-7658)
- Ida Arvidsson
- Karl Johansson
- Markus Wendler (ORCID: https://orcid.org/0009-0008-8293-745X)
- Ann‐Charlotte Kristoffersson
Institutions
- Lund University (SE)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-02-23
- DOI
- https://doi.org/10.3389/fcimb.2026.1705239
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00