Targeting Melanoma-Associated Fibroblasts to Overcome Cancer Stem Cell-Driven Drug Resistance
Activating Notch1 signaling in MAFs overcomes BRAF inhibitor resistance by disrupting cancer stem cell niches. This stromal-targeted approach represents a novel therapeutic strategy to complement surgical and systemic therapies in melanoma patients with drug-resistant disease.
Authors
- Nga Le (ORCID: https://orcid.org/0000-0001-8142-6035)
- Hongwei Shao (ORCID: https://orcid.org/0000-0001-9770-4132)
- Yulexi Y. Ortiz
- Zhao-Jun Liu (ORCID: https://orcid.org/0000-0001-8299-2899)
- Mecker Moller
Institutions
- University of Miami (US)
- University of Chicago (US)
Publication Details
- Journal
- Journal of the American College of Surgeons
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1097/xcs.0000000000001752
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00