Simultaneous electrophysiological and manometric evaluation of the sphincter of Oddi

(1) We successfully developed the first device capable of simultaneous electrophysiological and manometric detecting of the SO, with validation in both rabbit and canine models, confirming the correlation and technical feasibility of dual-parameter recording. (2) A human-compatible device was established for the first time, and its feasibility was confirmed; in healthy subjects, SO electrophysiological and manometric signals were linearly correlated in the fasted state. (3) Nardi test stimulation significantly increased both signal types, whereas cholinergic blockade effectively suppressed SO activity. (4) In SOD patients, both electrophysiological and manometric signals were markedly elevated. Finally, we demonstrated that after EPBD in SOD patients, the device remained capable of recording SO electrophysiological and manometric patterns, with both signals showing significant reductions. This provides a novel technical approach for the diagnosis and treatment of SOD.