Regular cannabinoid use and inflammatory biomarkers: Systematic review and hierarchical meta-analysis
Cannabinoid use is associated with concurrent pro- and anti-inflammatory modulation in non-medical populations, consistent with immunomodulatory effects rather than a uniform pro- or anti-inflammatory shift. Understanding the immunological impact of cannabinoids remains critical to anticipate long-term health consequences and guide therapeutic development.
Authors
- Riccardo Guglielmo (ORCID: https://orcid.org/0000-0002-2932-9235)
- Maria Giulia Nanni (ORCID: https://orcid.org/0000-0002-1085-4339)
- Andrea Escelsior
- Angela Muscettola (ORCID: https://orcid.org/0009-0008-8905-5142)
- Alessio Zizzi (ORCID: https://orcid.org/0009-0004-5772-6731)
- Mario Amore
- Gianluca Serafini
- Martino Belvederi Murri
- Alberto Inuggi
- Luigi Grassi
- Manuela Dall’Oro
Institutions
- University of Ferrara (IT)
- University of Genoa (IT)
- Union des Industries Ferroviaires Européennes (BE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2026-02-23
- DOI
- https://doi.org/10.1016/j.bbi.2026.106517
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00