SGLT2 Inhibitor Use and Cardiorenal Outcomes in Type 2 Diabetes With Liver Cirrhosis

In this cohort study of patients with T2D and liver cirrhosis, the use of SGLT2is was associated with substantially lower risks of adverse kidney, cardiovascular, and hepatic outcomes compared with DPP4is. These findings suggested significant cardiorenal and hepatic protection for SGLT2is in this high-risk population.

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Publication Details

Journal
JAMA Network Open
Published
2026-02-23
DOI
https://doi.org/10.1001/jamanetworkopen.2025.60429
Primary Topic
Diabetes Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00

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article

SGLT2 Inhibitor Use and Cardiorenal Outcomes in Type 2 Diabetes With Liver Cirrhosis

Laing-You Wu, Ming-Ju Wu, Chi-Jung Chung, Mu-Chi Chung et al.
JAMA Network Open
Diabetes Treatment and Management
article

SGLT2 Inhibitor Use and Cardiorenal Outcomes in Type 2 Diabetes With Liver Cirrhosis

Laing-You Wu, Ming-Ju Wu, Chi-Jung Chung, Mu-Chi Chung, Jeng-Jer Shieh, Tung-Min Yu
article en

Abstract

In this cohort study of patients with T2D and liver cirrhosis, the use of SGLT2is was associated with substantially lower risks of adverse kidney, cardiovascular, and hepatic outcomes compared with DPP4is. These findings suggested significant cardiorenal and hepatic protection for SGLT2is in this high-risk population.

JAMA Network OpenVol. 9(2)
National Chung Hsing University (TW), China Medical University (TW), Taichung Veterans General Hospital (TW), China Medical University Hospital (TW), National Taipei University (TW)
China Medical University Hospital, China Medical University, Division of Materials Research
Good health and well-being
Openalex Percentile: Top 47%
Diabetes Treatment and Management
DOIOpen Access PDFOpenAlex
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